Figure 2
Visual Gleason 4 appraisal overestimates burden of disease. (A) Bar plot of the proportion of Gleason 4 estimation average between two uropathologists (yellow) and digital estimation (blue). %G4 is plotted on the y-axis; each patient is plotted on the x-axis. A threshold of 50% g4 for clinical significance is shown as a red dashed line. Patient number on the x-axis is highlighted in bold and underlined if the digital measurement of their %G4 would lead to reclassification based on the digital value. Patient marked with * has ≥ 50% G4 in the digital measurement. (B) Bland–Altman plot representing the difference in measurement in the y-axis as visual %G4 – digital %G4. The x-axis represents the mean %G4 measurement of both techniques as (visual %G4 + digital %G4)/2. The bold black line represents complete agreement at 0. The purple dashed line corresponds to the bias at 18.71; the dotted purple line corresponds to the bias confidence interval (33.87–48.75). Dash and dotted blue lines correspond to the upper and lower limit of agreement and confidence intervals are plotted with dotted blue lines. Upper limit of agreement: 41.31 (33.87–48.75), lower limit of agreement: − 3.87 (− 11.31 to 3.56). Regression line is plotted as a continuous blue line.
