Table 3 Univariate and multivariate analyses for significant predictors of ROS1-rearranged adenocarcinomas.

From: CT features and disease spread patterns in ROS1-rearranged lung adenocarcinomas: comparison with those of EGFR-mutant or ALK-rearranged lung adenocarcinomas

Variables

Univariable analysis

Multivariable analysis*

HR (95% CI)

P-value

HR (95% CI)

P-value

Size

0.99 (0.97, 1.01)

0.244

  

Age

1.04 (1.01, 1.08)

0.026

1.06 (1.01, 1.12)

0.024

Location

0.84 (0.34, 2.06)

0.191

  

Air-bronchogram

0.25 (0.07, 0.87)

0.030

0.34 (0.01, 1.43)

0.142

Calcification

4.55 (0.59, 35.32)

0.148

  

Pleural retraction

0.48 (0.20, 1.16)

0.102

  

Central low-attenuation

0.89 (0.34, 2.32)

0.820

  

Pleural metastasis

0.61 (0.25, 1.49)

0.278

  

Pericardial metastasis

15.60 (4.10, 58.81)

 < 0.001

10.50 (2.10, 52.60)

0.005

Bone metastasis

0.53 (0.19, 1.52)

0.234

  

Nodal metastasis

5.46 (1.23, 24.52)

0.025

8.55 (1.14, 62.52)

0.037

Pleural effusion

2.53 (1.04, 6.17)

0.041

2.63 (0.81, 8.55)

0.107

  1. HR hazard ratio, CI confidence interval.
  2. *P-values < 0.1 in the univariate analysis were involved in the multivariate analysis.
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