Table 5 Comparison of demographic and clinical characteristics in ACLF patients induced by HBV reactivation with and without elevated ammonia.
From: Serum ammonia is a strong prognostic factor for patients with acute-on-chronic liver failure
Ammonia < 92.5 (n = 69) | Ammonia ≥ 92.5 (n = 37) | P | |
|---|---|---|---|
Male sex | 52 (74.3%) | 27 (75%) | 0.936 |
Complications, N (%) | |||
HE | 20 (28.6%) | 26 (72.2%) | < 0.001 |
Laboratory parameters | |||
Ferritin (ng/mL) | 2184.18 ± 1900.79 | 3894.96 ± 3519.22 | 0.008 |
TSH (mIU/L) | 0.88 ± 0.74 | 0.56 ± 0.56 | 0.014 |
WBC (10e9/L) | 6.75 ± 3.33 | 8.24 ± 3.86 | 0.041 |
AST | 220.64 ± 179.33 | 311.73 ± 252.35 | 0.034 |
TG (mmol/L) | 1.36 ± 0.55 | 1.13 ± 0.40 | 0.024 |
VLDL (mmol/L) | 1.12 ± 0.59 | 0.82 ± 0.48 | 0.01 |
INR | 2.14 ± 0.73 | 2.43 ± 0.50 | 0.032 |
PT (s) | 24.14 ± 7.95 | 27.40 ± 5.57 | 0.029 |
Organ failures | |||
Liver | 53 (75.7%) | 32 (88.9%) | 0.107 |
Kidney | 0 (0%) | 1 (2.8%) | 0.34 |
Cerebral | 5 (7.1%) | 16 (44.4%) | < 0.001 |
Coagulation | 11 (15.7%) | 18 (50%) | < 0.001 |
Circulation | 3 (4.3%) | 6 (16.7%) | 0.072 |
Lung | 4 (5.7%) | 3 (8.3%) | 0.687 |
Prognostic score | |||
MELD | 22.48 ± 5.83 | 26.19 ± 6.67 | 0.004 |
MELD-Na | 19.23 ± 8.30 | 22.88 ± 10.59 | 0.053 |
iMELD | 41.68 ± 7.60 | 46.24 ± 9.68 | 0.009 |
CLIF-C OF | 7.78 ± 1.63 | 10.19 ± 1.98 | < 0.001 |
CLIF-C ACLF | 37.29 ± 8.18 | 47.59 ± 10.33 | < 0.001 |
28-day mortality | 17 (24.3%) | 21 (58.3%) | 0.001 |
