Figure 4
Dietary fiber did not protect against Mst1-overexpression induced cardiac remodeling and fibrosis. (A) Shows expression of Col1a1 mRNA, (B) Col3a1 mRNA, (C) Ctgf mRNA, all relative to Gapdh mRNA with no significant difference found between any of the groups when adjusted for multiple comparisons (FDR q-value < 0.05). (D) Quantification of perivascular fibrosis as a percentage of vessel area and (E) representative images of perivascular fibrosis captured at 40 × magnification. (F) Quantification of interstitial fibrosis as a percentage of total field of view area and (G) Representative images of interstitial fibrosis captured at 400 × magnification. Scale bar indicates 100 μm. Error bars shown denote mean ± SEM. *P < 0.05. n = 2–7/group. 2-way ANOVA used to analyse data.
