Figure 1 | Scientific Reports

Figure 1

From: Three-dimensional data capture and analysis of intact eye lenses evidences emmetropia-associated changes in epithelial cell organization

Figure 1

Lens organization and cell distribution in the epithelium. (A) Schematic representation of a mammalian lens. (B) 3D maximum intensity projection of a murine lens epithelium from anterior pole (left) to meridional rows (right). A coronal section of the lens reveals its major constituents, the lens epithelial cells (LECs), and the lens fiber cells (LFCs). LECs occupy a monolayer on the anterior portion of the lens, whereas LFCs form the bulk of the tissue. LFCs are derived from LECs in the MR and shed their organelles while elongating during their differentiation and maturation. LECs are organized into different zones on the epithelium, with a low-density population (grey bracket) forming the central zone (CZ), a high density region containing actively replicating cells (yellow bracket) for the germinative zone (GZ), and a low-density region of aligned cells (blue bracket) in the meridional rows (MR).

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