Table 2 The effect of 4-week intermittent fasting from dawn to sunset on selected gene protein products (GPs) in subjects with metabolic syndrome.

A. The levels of the selected GPs that are significantly upregulated at the end of 4th week during 4-week intermittent fasting compared with the levels before 4-week intermittent fasting

AP5Z1

9907

Adaptor related protein complex 5 subunit zeta 1

6.201

0.005

− 5.971

0.073

0.230

0.945

VPS8

23355

VPS8 subunit of CORVET complex

5.730

0.043

− 4.106

0.107

1.624

0.396

INTS6

26512

Integrator complex subunit 6

4.234

0.041

− 2.529

0.247

1.705

0.174

IGFBP5

3488

Insulin like growth factor binding protein 5

4.008

0.015

− 1.704

0.183

2.305

0.218

POLRMT

5442

RNA polymerase mitochondrial

3.355

0.020

− 3.355

0.020

ND

KIT

3815

KIT proto-oncogene, receptor tyrosine kinase

2.891

0.033

− 4.040

0.011

− 1.149

0.484

CROCC

9696

Ciliary rootlet coiled-coil, rootletin

2.742

0.043

− 1.170

0.467

1.571

0.165

PIGR

5284

Polymeric immunoglobulin receptor

2.684

0.041

− 3.432

0.007

− 0.749

0.190

B. The levels of the selected GPs that are significantly downregulated at the end of the 4th week during 4-week intermittent fasting compared with the levels before 4-week intermittent fasting

POLK

51426

DNA polymerase kappa

− 2.987

0.026

2.156

0.302

− 0.831

0.520

CD109

135228

CD109 molecule

− 3.977

0.027

2.900

0.028

− 1.076

0.512

NIFK

84365

Nucleolar protein interacting with the FHA domain of MKI67

− 5.048

0.019

5.334

0.019

0.286

0.848

SRGN

5552

serglycin

− 6.286

0.009

1.725

0.619

− 4.560

0.080

C. The levels of the selected GPs that are significantly upregulated 1 week after 4-week intermittent fasting compared with the levels before 4-week intermittent fasting

PRKCSH

5589

Protein kinase C substrate 80K-H

− 0.642

0.336

6.834

0.012

6.191

0.031

CALR

811

Calreticulin

− 1.557

0.304

5.515

0.010

3.958

0.020

IGFBP4

3487

Insulin like growth factor binding protein 4

0.580

0.821

3.148

0.096

3.728

0.033

SEMA4B

10509

Semaphorin 4B

0.005

0.996

3.381

0.019

3.386

0.020

HIST1H2BB

3018

H2B clustered histone 3

0.532

0.734

2.124

0.163

2.656

0.044

HIST1H2BD

3017

H2B clustered histone 5

0.602

0.710

2.019

0.193

2.620

0.044

HIST1H2BA

255626

H2B clustered histone 1

ND

2.565

0.020

2.565

0.020

D. The levels of the selected GP that is significantly downregulated 1 week after 4-week intermittent fasting compared with the levels before 4-week intermittent fasting

PLAC1

10761

 Placenta enriched 1

− 3.632

0.186

− 3.439

0.082

− 7.071

0.032

E. The levels of the selected GP that is significantly upregulated both at the end of 4th week during 4-week intermittent fasting and 1 week after 4-week intermittent fasting compared with the levels before 4-week intermittent fasting

CALU

813

Calumenin

4.135

0.012

0.892

0.540

5.026

0.007

F. The levels of the selected GP that is significantly downregulated both at the end of 4th week during 4-week intermittent fasting and 1 week after 4-week intermittent fasting compared with the levels before 4-week intermittent fasting

CAMP

820

Cathelicidin antimicrobial peptide

− 5.020

0.012

1.277

0.559

− 3.743

0.038