Table 3 Adverse events in 15 studies on mycophenolate mofetil in neuromyelitis optica spectrum disorders.
Author | Total number of patients | Number of patients with adverse events (%) | Adverse events | Number of events (%) | Total number of discontinuation due to adverse effects (%) |
|---|---|---|---|---|---|
Jacob et al. 11 | 24 | 6 (25%) | Headache | 1 (4.2%) | 1 (4.2%) due to low white blood cell counts |
Constipation | 1 (4.2%) | ||||
Easy bruising | 1 (4.2%) | ||||
Anxiety | 1 (4.2%) | ||||
Hair loss | 1 (4.2%) | ||||
Diarrhea and abdominal pain | 1 (4.2%) | ||||
Low white blood cell counts | 1 (4.2%) | ||||
Huh et al.27 | 58 | 14 (24.13%) | Rash | 1 (1.7%) | 1 (1.7%) due to rash |
Amenorrhea | 2 (3.4%) | ||||
Herpes zoster | 1 (1.7%) | ||||
Cystitis | 3 (5.2%) | ||||
Pneumonia | 1 (1.7%) | ||||
Hypotension | 1 (1.7%) | ||||
Fatigue | 1 (1.7%) | ||||
Mild hair loss | 4 (6.9%) | ||||
Mealy et al.32 | 28 | NR | NR | NR | 0 (0%) |
Torres et al.23 | 11 | 4 (36%) | Sun sensitivity | NR | NR |
Recurrent infection | NR | ||||
Chen et al.16 | 62 | 3 (4.8%) | Mild hair loss | 2 (3.2%) | 0 (0%) |
Mildly elevated liver enzyme (After reused, no elevated liver enzyme) | 1 (1.6%) | ||||
Jeong et al.18 | 34 | NR | NR | NR | 0 (0%) |
Xu et al.19 | 38 | 2 (5.3%) | Agranulocytosis | 1 (2.6%) | 2 (5.3%) due to agranulocytosis, amenorrhea |
Amenorrhea | 1 (2.6%) | ||||
Chen et al.17 | 105 | 5 (4.8%) | Mild hair loss | 3 (2.9%) | 0 (0%) |
Mildly elevated liver enzyme | 1 (1.0%) | ||||
Phlegm on normal CT chest | 1 (1.0%) | ||||
Montcuquet et al.20 | 67 | 9 (13.4%) | Gastrointestinal side effects | 6 (9.0%) | 9 (13.4%) |
Infection | 3 (4.5%) | ||||
Deranged liver enzyme | 18 (20%) | ||||
Hyperbilirubinemia | 2 (2.2%) | ||||
Respiratory infection | 11 (12.2%) | ||||
Urinary tract infection | 5 (5.6%) | ||||
Varicella-zoster virus infection | 5 (5.6%) | ||||
Anemia | 6 (6.7%) | ||||
Leukopenia | 4 (4.4%) | ||||
Rectal cancer | 1 (1.1%) | ||||
Renal insufficiency | 1 (1.1%) | ||||
Hair loss | 2 (2.2%) | ||||
Huang et al.25 | 90 | 39 (43%) | Diarrhea | 2 (2.2%) | 8 (9%) |
Jiao et al.15 | 109a | 21 (19%) | Hair loss | 5 (4.6%) | 1 (0.9%) |
Mildly elevated liver enzyme | 3 (2.8%) | ||||
Diarrhea and abdominal pain | 2 (1.8%) | ||||
Constipation | 1 (0.9%) | ||||
Leukopenia | 3 (2.8%) | ||||
Thrombocytopenia | 1 (0.9%) | ||||
Shingles | 2 (1.8%) | ||||
Herpes simplex infection | 2 (1.8%) | ||||
Headache | 2 (1.8%) | ||||
Chronic dermopathy of hands and nail | 1 (0.9%) | ||||
Mealy et al.24 | 245 | NR | NR | NR | NR |
Yang et al.21 | 30 | 3 (10%) | Mildly elevated liver enzyme | 2 (6.7%) | 0 (0%) |
Nausea | 1 (3.3%) | ||||
Zhou et al.26 | 31 | NR | NR | NR | NR |
Poupart et al. 22 | 42 | 5 (11.9%)b | Serious infection events | 5 (11.9%) | 5 (11.9%) due to thrombocytopenia, arthromyalgia, Gastrointestinal side effects |
