Table 3 Incidence of hydatidiform mole (HM) reported in population-based studies since 1990.

From: Decreasing incidence of registered hydatidiform moles in Denmark 1999–2014

Author (year)

Population

Data source

N/R

Period

No

Incidence per 1000 total (complete HM/partial HM)

Pregnancies

Viable conceptions*

Deliveries

Live births

Scandinavia

Present study

Denmark

The Danish Pathology Registry

N

1999–2014

1976

  

1.98 (0.9a/1.08)

 

2007–2014

863

1.23 (0.61a/0.62)

1.79

Olsen et al.37

Denmark

The Danish National Patient Registry/The Danish Cancer Registry

N

1977–1992

1520

1.1b

   

Salehi et al.26

Sweden

The Swedish Cancer Register/The Inpatient Register

N

1973–2004

3844

  

1.2c

 

Joneborg et al.5

Stockholm County, Sweden

The Regional Cancer Register of Stockholm County/The Regional Pathology data base

R

1991–2010

956

 

1.48d

2.08e

 

Flam et al.36

Stockholm County, Sweden

The Regional Cancer Register of Stockholm County/medical records

R

1975–1988

393

0.9f

 

1.5

 

Loukovaara et al.4

Finland

The hospital discharge registry of the National Research and Development Center for Welfare and Health

N

1975–2001

1659

  

0.98

 

Europe

Savage et al.34

England and Wales

Databases of the Trophoblastic Disease Centres at Charing Cross Hospital (London) and Weston Park Hospital (Sheffield)

N

2000–2009

13,583

 

1.65g (0.70/0.95)

2.13h

 

Savage et al.27

England and Wales

Databases of the Trophoblastic Disease Centres at Charing Cross Hospital (London) and Weston Park Hospital (Sheffield)

N

1998–2007

14,161

 

1.69i

2.17h

 

Tham et al.33

Northern England and North Wales

The Trophoblastic Screening and Treatment Centre, Weston Park Hospital (Sheffield)

R

1991–1999

3637

   

1.38

Eysbouts et al.6

The Netherlands

A national pathology database, PALGA

N

1994–2013

5135

  

1.36 (0.52/0.67)

 

Lybol et al.11

The Netherlands

A national pathology database, PALGA

N

1995–2008

3668

  

1.34 (0.47/0.69)

 

Parazzini et al.25

Lombardy, Northern Italy

Integrated Patients Database of the Lombardy Region

R

1996–2008

1433

1.04j

   

USA/Canada

Altman et al.8

Nova Scotia, Canada

Nova Scotia Gestational Trophoblastic Disease Registry

N

1990–2005

420

2.20k (0.71/1.45)

 

2.64l (0.93/1.71)

2.66 (0.94/1.72)

Smith et al.32

New Mexico, USA

The New Mexico Tumor Registry

N

1988–1997

389

 

1.20m (0.81/0.39)

 

1.42 (0.96/0.46)

Asia

Yuk et al.22

South Korea

National Inpatient Sample, extracted records of 13% of patient per year

N

2009–2015

285

1.10n (0.10/0.10)

   

Kim et al.7

Korea

Korea medical insurance system

N

1991–1994

5855

  

2.05

 

Matsui et al.23

Chiba Prefecture, Japan

Questionnaires registration system

R

1985–2002

1876

 

1. 5o (0.83/0.67)

  

Matsui et al.24

Chiba Prefecture, Japan

Questionnaires registration system

R

1974–2000

3778

   

2.27

  1. N/R: N, National studies concerned one country (for USA/Canada: one state/province). R, Regional studies concerned one well-defined region. No: Number of hydatidiform moles.
  2. *Incidences listed here where either referred to as “viable conceptions” and/or it appeared that miscarriages were not included in the denominator.
  3. aHM not registered as PHM.
  4. bPregnancies: live births, stillbirths, induced abortions, and spontaneous abortions.
  5. cDeliveries: live births and stillbirths from gestational age 28 or later.
  6. dViable conceptions: deliveries and pregnancy terminations.
  7. eDeliveries: live births and stillbirths (multiple births counted as one delivery).
  8. fPregnancies: spontaneous, missed, and legal abortions, ectopics and deliveries.
  9. gConceptions: live births, stillbirths, terminations and moles.
  10. hMaternities: live births and stillbirths.
  11. iConceptions: live births, stillbirths, terminations, and moles.
  12. jPregnancies: births, spontaneous or induced abortions, ectopic pregnancies and hydatidiform moles.
  13. kPregnancies: live births, stillbirths, induced abortions, miscarriages and ectopic pregnancies.
  14. lDeliveries: live births and stillbirths 20 or more weeks of gestational age.
  15. mPregnancies: live births, fetal deaths (stillbirths of > 20 weeks of gestational age or 500 g) and induced abortions (not first trimester abortion or ectopic pregnancies).
  16. nPregnancies: GTD cases, ectopic pregnancies, abortions and deliveries.
  17. oPregnancies: live births, stillbirths and therapeutic abortions.