Figure 4
From: Blood RNA signatures predict recent tuberculosis exposure in mice, macaques and humans
Time since TB exposure in humans is associated with alteration in CD4 + T cell proportion and immune activation pathways. Changes in CD4 + T cell percentages (A,B) and NK cell percentages (C,D) in GC6-74 healthy household contacts cohort at baseline (n = 104 in A,C; n = 272 in B,D), 6 month (A,C; n = 79) and 18 month (B,D; n = 64) time points after active TB exposure were determined by cell-type deconvolution (P from linear mixed model). Boxplots represent medians with interquartile ranges. (E) Top immunity related enriched canonical pathways in the 250-gene RNA signature of time since exposure to active TB index case (6 months vs. baseline) by IPA (P from Fisher’s Exact test).
