Figure 2
Substance P restores impaired glucose regulation by modulating serum obese/insulin resistance-related markers. Substance P (SP) was injected into LETO or OLETF rats from postnatal 27 weeks for 4 weeks; (a) results of the glucose tolerance test (GTT) in LETO and OLETF rats at postnatal 31 weeks were evaluated. (b)–(f) Serum biochemical and growth factors were quantified at 2 and 4 weeks post SP injection; p-values of less than 0.05 were considered statistically significant (*p < 0.05, **p < 0.01, ***p < 0.001). At: NK-1R antagonist. N = 10/group.
