Figure 1 | Scientific Reports

Figure 1

From: Inhibition of eNOS by L-NAME resulting in rat hind limb developmental defects through PFKFB3 mediated angiogenetic pathway

Figure 1The alternative text for this image may have been generated using AI.

NOSs inhibition leads to late embryonic hind limb developmental defect. (A) Pregnant rats were consecutive administration L-NAME that started at embryonic day 13.5 (E13.5) by peritoneal injection, the embryos were harvest at different time point and multiple phenotypes were check. L-NAME administration induced embryonic hind limb developmental defects, which account for 20%. Approximately 5% embryos displayed fore limb hemorrhage. In addition, no more than 2%, shown cerebral defect, or embryonic lethality. (B) Whole mount images to show hind limb developmental defect after inhibition of NO production. Images obtained from Nikon SMZ745 microscope, Scale bar: 1 cm.

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