Figure 7
From: Rab35 and its effectors promote formation of tunneling nanotubes in neuronal cells
Proposed model of Rab35-dependent TNT formation: ACAP2, a downstream effector of Rab35 and a GAP of ARF6, is recruited by Rab35 to the ARF6- GTP positive vesicular membrane compartments, which inactivates ARF6 thus enabling enrichment of the membrane with PI4P. EHD1 is subsequently recruited to the same compartment due to its affinity for PI4P. This pathway promotes TNT formation, highly likely by supplying the growing TNT with vesicular membrane.
