Table 4 CMP-associated proteins with differential expression between the clusters with protein functions.

From: Late first trimester circulating microparticle proteins predict the risk of preeclampsia < 35 weeks and suggest phenotypic differences among affected cases

Abbreviation

Name

Function

Gene

Associated cluster

p value

Bonferroni correction

IGJ

Immunoglobulin J chain

IgA/IgM binding

JCHAIN

1

0.012

0.372

ZN251

Zinc finger protein 251

RNA transcription

ZNF251

1

0.022

0.697

ECM1

Extracellular matrix protein 1

Angiogenesis

ECM1

1

0.027

0.845

CD5L

CD5 antigen-like

Lipid synthesis regulator

CD5L

1

0.047

1.453

A2MG

Alpha-2-macroglobulin

Coagulation

A2M

1

0.055

2.022

VTNC

Vitronectin

Cell adhesion/migration

VTN

2

8.16E−06

0.0003

PEDF

Pigment epithelium-derived factor

Angiogenesis inhibitor

SERPINF1

2

9.79E−05

0.003

CO4A

Complement C4-A

Complement activation

C4A

2

0.0005

0.017

THRB

Prothrombin

Blood coagulation

F2

2

0.001

0.033

B4E1Z4

Highly similar to Complement factor B

Highly similar to Complement factor B

n/a

2

0.004

0.109

CO3

Complement C3

Complement activation

C3

2

0.004

0.109

ANGT

Angiotensinogen

Angiotensin-activated signaling pathway

AGT

2

0.004

0.109

CO2

Complement C2

Complement activation

C2

2

0.005

0.142

PHLD

Phosphatidylinositol-glycan-specific phospholipase D

C-terminal protein lipidation

GPLD1

2

0.005

0.143

FA12

Coagulation factor XII

Coagulation

F12

2

0.015

0.462

CFAH

Complement factor H

Complement modulation

CFH

2

0.018

0.569

CAPS1

Calcium-dependent secretion activator 1

Vesicle exocytosis

CADPS

2

0.025

0.777

CRP

C-reactive protein

Acute-phase response

CRP

2

0.027

0.845

KNG1

Kininogen-1

Coagulation

KNG1

2

0.027

0.845

HEP2

Heparin cofactor 2

Coagulation

SERPIND1

2

0.033

1.020

HEMO

Hemopexin

Heme metabolic

HPX

2

0.039

1.221

PRG2

Bone marrow proteoglycan

Immune response

PRG2

2

0.047

1.453

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