Table 2 Significant SNPs regulating MIF and DDTL expression in the lung tissue dataset and results for the same SNPs from the GTEx (lung) dataset.
From: Genetic regulation of gene expression of MIF family members in lung tissue
SNP ID | MIF | DDTL | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Our results | GTEx | Our results | GTEx | |||||||||
FDR | Beta | Genotype of high expression | P value | NES | Genotype of high expression | FDR | Beta | Genotype of high expression | P value | NES | Genotype of high expression | |
rs140188 | 4.09E−31 | 1.05E−01 | CC | 3.90E−30 | 7.50E−01 | GG | 1E−314 | 6.45E−01 | CC | 8.40E−08 | − 2.60E−01 | CC |
rs140245 | 4.72E−31 | 1.05E−01 | AA | 1E−314 | 6.42E−01 | AA | ||||||
rs113413 | 1.59E−27 | 1.12E−01 | CC | 4.20E−31 | − 7.70E−01 | TT | 1E−314 | 6.98E−01 | CC | |||
rs6003980 | 1.01E−22 | 1.48E−01 | AA | 3.28E−298 | 9.18E−01 | AA | ||||||
rs1006771 | 2.06E−21 | 9.27E−02 | GG | 4.50E−45 | 8.90E−01 | TT | 2.04E−270 | 5.82E−01 | GG | 1.90E−08 | − 2.70E−01 | GG |
rs5760147 | 4.68E−18 | 8.67E−02 | CC | 7.70E−35 | − 8.10E−01 | AA | 1E−314 | 6.11E−01 | CC | |||
rs738807 | 2.93E−17 | − 1.20E−01 | CC | 1.51E−06 | − 2.13E−01 | CC | ||||||
rs140289 | 1.26E−16 | 9.29E−02 | TT | 1.20E−20 | 7.50E−01 | CC | 2.98E−104 | 4.98E−01 | TT | 1.20E−06 | − 2.70E−01 | TT |
rs5760176 | 1.50E−16 | 8.79E−02 | GG | 2.20E−36 | 8.40E−01 | AA | 1.93E−256 | 6.12E−01 | GG | 1.20E−06 | − 2.40E−01 | GG |
rs140199 | 3.99E−15 | 1.50E−01 | TT | 1.80E−99 | 8.15E−01 | TT | ||||||
rs17004811 | 1.36E−14 | 1.51E−01 | CC | 8.50E−15 | − 6.80E−01 | GG | 1.81E−112 | 8.63E−01 | CC | |||
rs1018743 | 3.40E−08 | 6.61E−02 | GG | 1.50E−14 | 6.50E−01 | TT | 2.75E−53 | 3.75E−01 | GG | |||
rs738809 | 9.10E−05 | 5.19E−02 | GG | 1.50E−09 | − 4.90E−01 | AA | 1.53E−51 | 3.56E−01 | GG | |||
rs915590 | 7.92E−04 | 8.48E−02 | AA | 1.80E−13 | 7.30E−01 | GG | 1.36E−39 | 5.52E−01 | AA | 9.50E−09 | − 3.90E−01 | AA |
rs1018744 | 2.61E−03 | 6.50E−02 | TT | 1.40E−11 | 7.50E−01 | CC | 2.55E−32 | 4.09E−01 | TT | 1.90E−06 | − 3.60E−01 | TT |
rs9624364 | 4.03E−03 | 8.41E−02 | AA | 2.88E−20 | 4.53E−01 | AA | ||||||
rs2858908 | 7.69E−03 | 7.46E−02 | AA | 3.10E−06 | 5.00E−01 | GG | 1.10E−26 | 4.64E−01 | AA | 6.20E−06 | − 3.30E−01 | AA |
rs405597 | 4.59E−02 | 8.12E−02 | CC | 3.33E−07 | 3.22E−01 | CC | ||||||
rs11703791 | 3.59E−03 | − 1.09E−01 | CC | – | – | – | ||||||
rs6003909 | – | – | – | 1.49E−03 | 1.47E−01 | AA | ||||||
rs131445 | – | – | – | 3.29E−03 | 1.32E−01 | CC | ||||||
rs9608216 | – | – | – | 3.70E−03 | − 2.40E−01 | CC | ||||||
rs9620328 | – | – | – | 8.14E−03 | − 1.12E−01 | CC | ||||||
rs12157360 | – | – | – | 2.53E−13 | 2.63E−01 | GG | ||||||
rs422674 | – | – | – | 2.47E−06 | − 1.47E−01 | CC | ||||||
rs9608247 | – | – | – | 3.15E−02 | 1.24E−01 | AA | ||||||
LD blocks | ||||||||||||
rs5751770* | 3.64E−22 | 9.08E−02 | TT | 2.50E−55 | 9.20E−01 | CC | 1E−314 | 5.96E−01 | TT | 4.30E−09 | − 2.70E−01 | TT |
rs5751759 | 2.71E−26 | − 1.27E−01 | AA | 5.05E−12 | − 2.40E−01 | AA | ||||||
rs4461358 | 2.42E−17 | 8.34E−02 | CC | 8.30E−30 | − 8.30E−01 | TT | 4.15E−277 | 5.81E−01 | CC | |||
rs4822453 | 1.07E−19 | 8.72E−02 | GG | 2.90E−46 | 8.80E−01 | TT | 1E−314 | 5.89E−01 | GG | 1.70E−07 | − 2.50E−01 | GG |
rs3884794 | 3.88E−16 | 8.52E−02 | CC | 2.90E−25 | 8.20E−01 | AA | 4.17E−162 | 5.37E−01 | CC | |||
rs738806 | 1.03E−12 | 7.74E−02 | AA | 2.30E−17 | 6.50E−01 | GG | 1.24E−68 | 4.05E−01 | AA | |||
rs5760101 | 1.61E−11 | 7.53E−02 | TT | 2.80E−26 | 7.60E−01 | CC | 5.27E−113 | 4.88E−01 | TT | |||
rs2000467 | 3.94E−10 | 7.18E−02 | AA | 6.40E−46 | 9.00E−01 | GG | 4.03E−157 | 5.44E−01 | AA | 2.60E−07 | − 2.50E−01 | AA |
rs4822461 | 7.03E−10 | 8.52E−02 | GG | 1.70E−13 | 7.00E−01 | TT | 1.15E−64 | 4.81E−01 | GG | 1.30E−08 | − 3.70E−01 | GG |
rs6004011 | 2.90E−03 | 5.56E−02 | GG | 4.00E−13 | − 6.50E−01 | TT | 9.24E−53 | 4.39E−01 | GG | |||
rs1984309 | 1.69E−02 | 4.18E−02 | GG | 3.40E−09 | 5.00E−01 | AA | 1.31E−36 | 3.08E−01 | GG | |||
rs5760090 | – | – | – | 2.89E−58 | − 3.84E−01 | CC | ||||||
rs9612498 | – | – | – | 6.44E−56 | − 3.29E−01 | CC | ||||||
rs17004046 | – | – | – | 1.62E−18 | 2.91E−01 | TT | ||||||
rs9624472 | – | – | – | 8.06E−06 | 2.30E−01 | GG | ||||||
rs17004049 | – | – | – | 2.38E−04 | 2.91E−01 | GG | ||||||
rs2236624 | – | – | – | 2.46E−02 | − 1.14E−01 | CC | ||||||
rs5760062 | – | – | – | 1.13E−02 | 2.10E−01 | CC | ||||||
rs9612623 | – | – | – | 2.05E−02 | − 1.02E−01 | GG | ||||||
