Figure 5
From: Long-acting antibody ligand mimetics for HER4-selective agonism
HER4-specific antibody agonists. The top NRG1 selective variant, 1F7, was introduced into the ALM6 scaffold and subsequently expressed and purified. Biolayer interferometry analysis showed HER4 binding (A) but no HER3 binding (B) at concentrations of up to 1,000 nM. BLU biolayer interferometry units.
