Table 1 Equilibrium binding of NRG1 ALM designs.

From: Long-acting antibody ligand mimetics for HER4-selective agonism

Constructs

HER4 binding KD

NRG1-HSA

460 nM

ALM1

NB

ALM2

NB

ALM3

 > 10 μM

ALM4

5.6 μM

ALM5

560 nM

ALM6

440 nM

NRG1-MFc

640 nM

  1. KD = equilibrium dissociation constant; NB no binding.
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