Table 3 In vivo mouse PK analysis of MFc fusion proteins and ALMs*.

From: Long-acting antibody ligand mimetics for HER4-selective agonism

Construct

Dose

Cmax

AUCINF

CL

t1/2

(mg/kg)

(µg/mL)

(h*µg/mL)

(mL/h/kg)

(h)

NRG1-MFc

5

21

17

288

1.4

1F7-MFc

5

17

17

292

6.6

ALM6

5

27

26

194

1.4

ALM6-1F7

5

41

91

55

6.6

  1. *PK parameters were determined by non-compartmental analysis with model 201. AUCINF = area under the concentration–time curve; CL clearance; Cmax = peak concentration; t1/2 = terminal half-life.
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