Table 2 Prevalence of genotypes and alleles of PRM1 and PRM2 polymorphisms.

First author, publication year	PRM1 polymorphism	Case			Control			Case		Control		HWE*
First author, publication year	PRM1 polymorphism	CC	CA	AA	CC	CA	AA	C	A	C	A	HWE*
Tanaka, 2003²⁴	rs737008	125	86	15	129	117	24	336	116	375	165	0.728
Aoki, 2006²⁵	rs737008	32	79	81	12	43	41	143	241	67	125	0.889
Ravel, 2007²⁶	rs737008	38	131	112	14	51	46	207	355	79	143	0.981
Imken, 2009²⁸	rs737008	16	55	64	16	74	70	87	183	106	214	0.578
Tuttelmann, 2010²⁹	rs737008	23	63	85	8	28	41	109	233	44	110	0.338
Jodar, 2011a²³	rs737008	12	64	80	14	41	47	88	224	69	135	0.302
Jodar, 2011b²³	rs737008	2	28	30	4	20	26	32	74	28	72	0.955
Venkatesh, 2011³⁰	rs737008	56	20	24	48	24	28	132	68	120	80	< 0.001
Grassetti, 2012³¹	rs737008	15	55	40	4	29	20	85	135	37	69	0.137
He, 2012³²	rs737008	161	112	31	209	142	25	434	174	560	192	0.894
Siasi, 2012³³	rs737008	22	32	42	24	29	47	76	116	77	123	< 0.001
Nabi, 2018³⁴	rs737008	33	47	12	21	51	15	123	61	93	81	0.096
Dehghanpour, 2019³⁵	rs737008	0	62	3	17	37	11	62	68	71	59	0.232
Ravel, 2007²⁶	rs2301365	184	87	10	71	36	4	455	287	178	44	0.829
Gazquez, 2008²⁷	rs2301365	114	90	16	68	30	3	318	122	166	36	0.887
Imken, 2009²⁸	rs2301365	85	45	5	113	42	5	215	55	268	52	0.652
Jodar, 2011a²³	rs2301365	88	55	13	60	38	4	231	81	158	46	0.501
Jodar, 2011b²³	rs2301365	25	27	1	26	17	7	77	29	69	31	0.176
He, 2012³²	rs2301365		100	17	241	112	16	474	134	594	144	0.517
Yu, 2012³⁴	rs2301365	61	70	26	17	19	1	192	122	53	21	0.109
Jamali, 2016³⁵	rs2301365	80	39	11	109	20	1	199	61	238	22	0.937
Jiang, 2017³⁶	rs2301365	378	229	29	277	144	21	985	287	698	187	0.681
Aydos, 2018³⁷	rs2301365	58	38	4	92	8	0	154	46	192	8	0.676

First author, publication year	PRM2 polymorphism	GG	GC	CC	GG	GC	CC	G	C	G	C
Tanaka, 2003²⁴	rs1646022	127	80	19	127	118	24	224	118	372	166	0.645
Aoki, 2006²⁵	rs1646022	77	30	85	39	13	44	184	200	91	101	< 0.001
Tuttelmann, 2010²⁸	rs1646022	57	66	36	22	28	23	180	138	74	72	0.046
Venkatesh, 2011³⁰	rs1646022	100	0	0	98	0	2	200	0	196	4	< 0.001
Grassetti, 2012³¹	rs1646022	30	62	18	18	26	9	122	98	62	44	0.940
Jamali, 2016³⁵	rs1646022	4	39	7	93	31	6	207	53	217	43	0.120
Jiang, 2017³⁶	rs1646022	35	266	335	47	162	233	336	936	256	478	0.021
Nabi, 2018³⁸	rs1646022	31	59	10	36	56	8	121	79	128	72	0.031
Dehghanpour, 2019³⁹	rs1646022	29	25	11	20	41	4	83	47	81	49	0.005

First author, publication year	PRM2 polymorphism	CC	CA	AA	CC	CA	AA	C	A	C	A
Tanaka, 2003²⁴	rs2070923	125	82	19	127	118	25	332	120	372	168	0.747
Aoki, 2006²⁵	rs2070923	93	27	72	40	12	44	213	171	81	100	< 0.001
Tuttelmann, 2010²⁹	rs2070923	78	55	26	38	26	9	211	107	102	44	0.187
Venkatesh, 2011³⁰	rs2070923	55	20	25	60	0	40	130	70	120	80	< 0.001
Grassetti, 2012³¹	rs2070923	42	54	14	23	25	5	138	82	71	35	0.628
He, 2012³²	rs2070923	87	57	162	99	73	204	231	381	271	481	< 0.001
Nabi, 2018³⁸	rs2070923	15	57	28	23	34	43	87	113	80	120	0.003
Dehghanpour, 2019³⁹	rs2070923	21	22	22	11	26	28	64	66	48	56	0.254

HWE Hardy–Weinberg equilibrium.
*P-values of HWE for control group. The study of Jodar et al.¹⁷ included two studies.

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