Table 5 Meta-regression analysis for PRM1 rs737008, PRM1 rs2301365, PRM2 rs2070923, and PRM2 rs1646022 polymorphisms based on publication year.

Polymorphism	Indexes	Allele	Homozygote	Heterozygous	Recessive	Dominant
PRM1 rs737008	R	0.152	0.639	0.573	0.572	0.066
	Adjusted R²	− 0.66	0.354	0.267	0.266	− 0.086
	P-value	0.620	0.019	0.041	0.041	0.831
PRM1 rs2301365	R	0.545	0.660	0.619	0.630	0.241
	Adjusted R²	0.209	0.365	0.306	0.322	− 0.060
	P-value	0.104	0.038	0.057	0.051	0.503
PRM2 rs1646022	R	0.225	0.698	0.267	0.358	0.534
	Adjusted R²	− 0.085	0.414	− 0.083	0.004	0.183
	P-value	0.561	0.036	0.522	0.344	0.139
PRM2 rs2070923	R	0.234	0.059	0.012	0.249	0.251
	Adjusted R²	− 0.103	− 0.163	− 0.166	− 0.094	− 0.093
	P-value	0.576	0.889	0.977	0.552	0.549

Allele: A vs. C, homozygous: AA vs. CC, heterozygous: AG vs. CC, recessive: AA + CA vs. CC, and dominant: AA vs. CA + CC, for PRM1 rs737008, PRM1 rs2301365, and PRM2 rs2070923 polymorphisms. Allele: C vs. G, homozygous: CC vs. GG, heterozygous: GC vs. GG, recessive: CC + GC vs. GG, and dominant: CC vs. GC + GG, for PRM2 rs1646022 polymorphism. Bold numbers indicate statistically significant differences.

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