Table 1 Cutaneous malignant melanoma (CMM) related genes used as seeds by network propagation algorithms.
Genes | Riska | Associated pathway/driver |
|---|---|---|
ACD | High | Telomere |
TPP1 | High | Telomere |
BAP1 | High | Cell cycle |
CDKN2A | High and low | Cell cycle |
CDK4 | High | Cell cycle |
POT1 | High | Telomere |
TERF2IP | High | Telomere |
IRF4 | Intermediate | Pigmentation |
MC1R | Intermediate | Pigmentation |
MITF | Intermediate | Melanocyte differentiation |
SLC45A2 | Intermediate | Pigmentation |
AGR3 | Low | Unknown |
ARNT | Low | Xenobiotic metabolism |
ASIP | Low | Pigmentation |
ATM | Low | DNA repair |
CASP8 | Low | Apoptosis |
CCND1 | Low | Cell cycle |
CDKAL1 | low | Unknown |
CDKN2B | Low | Cell cycle |
FTO | Low | DNA repair |
HERC2 | Low | Pigmentation |
KITLG | Low | Pigmentation |
MTAP | Low | 9p21.3 locus |
MX2 | Low | Unknown |
OBFC1 | Low | Telomere |
OCA2 | Low | Pigmentation |
PARP1 | Low | DNA repair |
PLA2G6 | Low | Nevi |
SLC24A5 | Low | Pigmentation |
TERT | Low & high | Telomere, Nevi |
CLPTM1L | Low & high | Telomere, Nevi |
RAD23B | Low | DNA repair |
TMEM38B | Low | DNA repair |
TYR | Low | Pigmentation |
TYRP1 | Low | Pigmentation |
BRAF | Unknown | Driver |
NRAS | Unknown | Driver |
HRAS | Unknown | Driver |
NF1 | Unknown | Driver |
RAC1 | Unknown | Driver |
MAP2K1 | Unknown | Driver |
TP53 | Unknown | Driver |
ARID2 | Unknown | Driver |
DDX3X | Unknown | Driver |
PPP6C | Unknown | Driver |
PTEN | Unknown | Driver |
RB1 | Unknown | Driver |
