Table 3 Known high-risk cutaneous malignant melanoma (CMM) genes and their first interacting neighbors identified in the interconnected gene cluster by GeneMANIA.

From: Using whole-exome sequencing and protein interaction networks to prioritize candidate genes for germline cutaneous melanoma susceptibility

Melanoma high risk gene

Interacting partner

ACD

TERT

OBFC1

POT1

TERF1

TERF2IP

TPP1

POT1

TERT

BAP1

PTEN

CDKN2A

GGA3

ATR

CCND1

CDK4

CDK6

EIF3A

HRAS

MAP2K1

TP53

CDK4

CDKN2A

CCND1

CDKN2B

PKM

RB1

CDK6

POT1

ACD

DDX3X

PROSER2

IL1RN

PRKDC

TERF2IP

ECI1

CYP4F11

OBFC1

TPP1

TERT

TERF1

TERF2IP

DDX24

FABP2

IL1RN

ACD

OBFC1

PARP1

TERF1

  1. Genes in bold are found in our candidate gene list from WES analysis.
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