Table 3 SNR of (1.3, 1.3) ppm in 2D lipid composition spectra using DQF-COSY.

	Algorithms	Tumour specimens (N = 17)	P-value	Healthy volunteers (N = 15, 30 voxels)	P-value	Patients Peritumoural adipose tissue (N = 15)	P-value	Patients Tumours in vivo (N = 10)	P-value
External reference	Equal	59.5 (41.6–105.8)		469.5 ± 127.7		309.9 ± 112.5		37.8 (19.7–57.0)
	Signal	75.4 (52.3–131.3)		621.4 ± 239.6		444.6 ± 215.9		42.9 (25.8–81.0)
	S/N	76.9 (53.2–133.0)		637.4 ± 235.2		462.2 ± 219.2		46.1 (25.2–82.4)
	S/N²	78.2 (53.3–133.4)		645.0 ± 229.1		472.4 ± 218.4		47.7 (24.8–81.9)
	WSVD	82.3 (56.8–133.1)	0.246	825.6 ± 304.5	0.003	581.1 ± 291.6	0.022	50.5 (31.8–101.9)	0.241
	nd-comb	82.4 (56.7–133.8)	0.049	812.1 ± 300.7	< 0.001	570.7 ± 291.0	< 0.001	48.5 (33.4–100.4)	0.575
	AOC	82.5 (56.8–133.9)	0.003	825.7 ± 305.2	0.003	582.2 ± 293.2	0.100	50.2 (33.4–101.3)	0.575
Internal reference	Equal	39.5 (30.8–103.9)		457.4 ± 148.4		311.4 ± 154.6		37.4 (18.2–57.0)
	Signal	54.1 (41.0–129.9)		609.8 ± 248.5		433.2 ± 230.8		41.2 (23.9–82.9)
	S/N	57.5 (41.9–131.8)		624.9 ± 244.5		449.2 ± 237.2		43.6 (24.4–82.5)
	S/N²	60.0 (41.6–132.2)		630.0 ± 240.4		482.5 ± 239.1		44.9 (24.6–81.4)
	WSVD	81.9 (57.2–136.4)	–	833.6 ± 308.6	–	584.6 ± 294.7	–	49.8 (32.6–102.8)	–
	nd-comb	64.2 (50.6–135.2)	< 0.001	743.6 ± 319.8	0.001	543.6 ± 310.7	0.007	43.1 (27.5–99.3)	0.028
	AOC	60.0 (46.1–130.8)	< 0.001	781.4 ± 338.1	0.005	552.6 ± 312.9	0.034	46.0 (28.6–98.9)	0.059

The median SNR and interquartile range are shown for non-normally distributed data while mean and standard deviation are shown for normally distributed data. P-value represents the comparison on SNR between the noise decorrelated algorithms using repeated measures ANOVA or Wilcoxon signed-rank tests. The SNR of the linear algorithms is also reported for reference purposes. Results are presented with WSVD_i as a reference for comparison.
AOC adaptively optimised combination, CV coefficient of variance, nd-comb noise decorrelated combination, WSVD whitened singular value decomposition.

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