Table 4 Binding of compounds to the rat A3R.

From: Pharmacological characterisation of novel adenosine A3 receptor antagonists

 

pKi

n

MRS 1220

6.74 ± 0.04

5

K1

6.07 ± 0.05

5

K10

4.19 ± 0.09

3

K17

4.60 ± 0.09

3

K18

4.60 ± 0.04

3

K20

5.71 ± 0.03

5

K23

5.93 ± 0.04

5

K25

6.37 ± 0.06

5

K32

4.05 ± 0.10

3

  1. Equilibrium dissociation constant of MRS 1220 and K compounds as determined through NanoBRET ligand-binding (pKi).
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