Figure 3

Apoe^−/−Nba2.Yaa (apoe^−/−.Yaa) mice exhibit elevated anti-dsDNA and anti-ApoA-1 circulating antibodies. Bar graphs represent the median ± s.e.m. of (a) anti-dsDNA IgG and (b) anti-ApoA-1 IgG autoantibody quantification in the serum, measured as optical density (OD) in Apoe^−/− or Apoe^−/−Nba2.Yaa mice on HCD (n = 8–10 mice/group). The nonparametric Mann–Whitney U test was used for statistical analysis: *p ≤ 0.05. Spearman’s rank correlation coefficients between anti-dsDNA IgG and anti-ApoA-1 IgG (c), PLT (d), and Fibrous cap thickness (e). Spearman’s rank correlation coefficients between anti-ApoA-1 IgG and PLT (f) and Fibrous cap thickness (g).