Figure 4

Apoe^−/−Nba2.Yaa mice develop small kidney and splenomegaly. (a) Representative pictures of spleen size and weight quantification in Apoe^−/− or Apoe^−/−Nba2.Yaa (apoe^−/−.Yaa) mice. Bar graph represents the median ± s.e.m. of spleen weight quantification in Apoe^−/− or Apoe^−/−Nba2.Yaa mice on HCD. (b) Representative pictures of kidney size and weight quantification in Apoe^−/− or Apoe^−/−Nba2.Yaa mice. Bar graph represents the median ± s.e.m. of kidney weight quantification. Spearman’s rank correlation coefficients between anti-dsDNA IgG and spleen weight (c) or LN weight (d). Spearman’s rank correlation coefficients between anti-ApoA-1 IgG and spleen weight (e) or LN weight (f). (g) Quantification of serum blood urea nitrogen (BUN) measurement in Apoe^−/− or Apoe^−/−Nba2.Yaa mice on HCD (n = 8–10 mice/group). The nonparametric Mann–Whitney U test was used for statistical analysis: *p ≤ 0.05; **p ≤ 0.005.