Table 1 Clinical and laboratory parameters at sacrifice of adult ApoE−/− mice after 11 weeks of high-cholesterol diet.
From: Atherosclerotic plaque vulnerability is increased in mouse model of lupus
Mouse profile | apoe−/− (n = 10) | apoe−/−.Yaa (n = 8) | p-value |
|---|---|---|---|
Clinical features | |||
Body weight at baseline (g) | 26.3 (25.3–30.0) | 24.4 (24.1–25.2) | 0.037 |
Body weight at month 1 (g) | 28.0 (25.3–31.0) | 25.7 (25.5–26.1) | 0.245 |
Body weight at month 2 (g) | 30.3 (28.4–31.8) | 27.3 (26.5–28.1) | 0.003 |
Body weight at sacrifice (g) | 35.6 (34.9–36.7) | 30.7 (29.6–31.6) | 0.001 |
Lymph node weight (mg) | 99 (77–158) | 235 (185–290) | 0.003 |
Biochemical | |||
Total-c (mmol/l) | 31.5 (25.1–36.0) | 23.9 (18.1–29.2) | 0.120 |
LDL-c (mmol/l) | 27.8 (21.8–32.3) | 19.1 (14.8–23.9) | 0.083 |
HDL-c (mmol/l) | 10.7 (9.0–12.0) | 8.6 (5.6–9.4) | 0.120 |
TAG (mmol/l) | 1.1 (0.8–1.8) | 1.2 (0.9–1.8) | 0.859 |
FFA (mmol/l) | 1.4 (1.2–1.7) | 1.5 (1.4–1.7) | 0.450 |
Glycaemia (mmol/l) | 15.9 (12.2–19.3) | 16.1 (14.7–18.8) | 0.625 |
Haematology | |||
Hb (g/dl) | 10.7 (10.3–11.3) | 10.0 (8.7–11.7) | 0.477 |
RBC count (×106/μl) | 7.6 (7.0–7.9) | 6.5 (5.6–7.7) | 0.100 |
WBC count (×103/μl) | 4.8 (3.7–8.0) | 3.6 (1.6–4.9) | 0.138 |
Lymphocytes (×103/μl) | 3.1 (0.9–6.9) | 2.1 (1.3–3.8) | 0.832 |
PLT (×103/μl) | 1159 (937–1328) | 541 (305–813) | 0.005 |
Inflammation | |||
MPO (ng/ml) | 199.8 (164.8–265) | 239.15 (200.15–347.02) | 0.564 |
TIMP-1 (ng/ml) | 2.59 (1.66–2.95) | 2.65 (1.77–3.80) | 0.564 |
CXCL1 (pg/ml) | 238.64 (113.56–388.55) | 193.43 (171.56–341.79) | 1.000 |
