Figure 4
From: Targeted sequencing reveals the somatic mutation landscape in a Swedish breast cancer cohort
Mutational Signatures in the Swedish BC cohort. (A) The relative contribution of each sample to the three mutational signatures found in the Swedish cohort. The COSMIC signature 2 (green) is the APOBEC deaminase signature usually identified in BC. The COSMIC signature 5 (orange) is not clearly associated with a defined process but is found in many cancers. The COSMIC signature 6 (purple) is associated with a defective DNA mismatch repair. (B) The substitution motifs that define the three mutational signatures.
