Table 2 Origin and partial amino acid sequences of HA proteins of reassortant viruses.

From: Cell-penetrating peptide-mediated cell entry of H5N1 highly pathogenic avian influenza virus

Reassortant viruses

HA origins

Proteases

C-terminal amino acid sequences of HA1

PR8

A/Puerto Rico/8/34 (H1N1)

Trypsin

RSAKLRMVTGLRNIPSIQSR/

UT3040HA (R339G)/PR8

A/Vietnam/UT3040/04 (H5N1)

Trypsin

KSNRLVLATGLRNSPQGER/RR/K/K/R/

UT3040HA (R339G)/PR8

A/Vietnam/UT3040/04 (H5N1)

Furin

KSNRLVLATGLRNSPQGERRRKKR/

  1. Multiple basic amino acids critical for CPP activity are shown in bold font. The underlined letters and slashes indicate the mutation site at position 339 and the predicted sites of proteolytic cleavage, respectively.
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