Figure 2 | Scientific Reports

Figure 2

From: The transcription factor Sox10 is an essential determinant of branching morphogenesis and involution in the mouse mammary gland

Figure 2

Postnatal mammary gland development in mice with embryonal Sox10 deletion. (a–l) Carmine-alum and X-gal stainings were performed at P21 (a–c), P28 (d–f), P42 (g–i) and P56 (j–l) on Sox10+/+ (wt in a,d,g,j) and Sox10+/lacZ (b,c,e,f,h,i,k,l) mice. Inlays in right upper corner show magnifications of boxed areas in main panels. (m,n) The number of terminal end buds (TEB in m) and ductal tips (n) was quantified in mammary glands of Sox10+/+ (grey hatched bars) and Sox10+/lacZ (black hatched bars) mice at P21, P28, P42 and P56 (n = 4–7). Presentations are as absolute cell numbers ± SEM. Statistical significance between age-matched Sox10+/+ and Sox10+/lacZ was determined by Student`s t-test (***, P ≤ 0.001). Scale bar: 2 mm (a).

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