Table 2 Univariate and multivariate analyses of cancer special survival (CSS) and overall survival (OS) for patients with colorectal SRCC.
Variables | CSS | OS | ||||
|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||
P value | HR (95%CI) | P value | P value | HR (95%CI) | P value | |
Year at diagnosis | 0.826 | NI | 0.962 | NI | ||
2004–2007 | ||||||
2008–2011 | ||||||
2012–2015 | ||||||
Insured status | 0.443 | NI | 0.620 | NI | ||
Uninsured/unknown | ||||||
Any medicaid/insured | ||||||
Age | 0.731 | NI | < 0.001 | < 0.001 | ||
< 65 | Reference | |||||
≥ 65 | 1.486 (1.359, 1.624) | |||||
Gender | 0.176 | NI | 0.506 | NI | ||
Female | ||||||
Male | ||||||
Race | 0.149 | NI | 0.183 | NI | ||
Black | ||||||
White | ||||||
Other | ||||||
Primary site | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
Cecum–transverse colon | Reference | Reference | ||||
Descending colon–sigmoid | 1.196 (1.054, 1.358) | 0.005 | 1.211 (1.074, 1.365) | 0.002 | ||
Multiple | 1.466 (1.050, 2.048) | 0.025 | 1.395 (1.008, 1.930) | 0.044 | ||
Rectum | 1.334 (1.184, 1.503) | < 0.001 | 1.286 (1.119, 1.477) | < 0.001 | ||
Unknown | 1.368 (1.075, 1.740) | 0.011 | 1.326 (1.049, 1.675) | 0.018 | ||
Grade | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
Grade I/II | Reference | Reference | ||||
Grade III/IV | 1.768 (1.417, 2.205) | < 0.001 | 1.742 (1.426, 2.128) | < 0.001 | ||
Unknown | 1.763 (1.386, 2.242) | < 0.001 | 1.739 (1.397, 2.165) | < 0.001 | ||
Tumor size | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
≤ 5 cm | Reference | Reference | ||||
> 5 cm | 1.253 (1.128, 1.392) | < 0.001 | 1.202 (1.091, 1.325) | < 0.001 | ||
Unknown | 1.301 (1.143, 1.482) | < 0.001 | 1.294 (1.143, 1.465) | < 0.001 | ||
AJCC stage | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
I | Reference | Reference | ||||
II | 1.426 (0.976, 2.083) | 0.067 | 1.552 (1.149, 2.097) | 0.004 | ||
III | 4.794 (3.390, 6.780) | < 0.001 | 3.921 (2.960, 5.193) | < 0.001 | ||
IV | 12.086 (8.642, 17.099) | < 0.001 | 9.649 (7.271, 12.806) | < 0.001 | ||
Surgery | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
No surgery | Reference | Reference | ||||
Local tumor excision/partial colectomy | 0.595 (0.491, 0.722) | < 0.001 | 0.613 (0.510, 0.737) | < 0.001 | ||
Total colectomy | 0.710 (0.579, 0.871) | 0.001 | 0.745 (0.614, 0.940) | 0.003 | ||
Dissected lymph node | < 0.001 | 0.135 | < 0.001 | 0.042 | ||
None or biopsy | Reference | Reference | ||||
1–3 | 0.914 (0.672, 1.244) | 0.568 | 0.913 (0.685, 1.216) | 0.325 | ||
≥ 4 | 0.832 (0.693, 1.000) | 0.050 | 0.807 (0.679, 0.959) | 0.015 | ||
Chemotherapy | 0.084 | < 0.001 | < 0.001 | < 0.001 | ||
No/unknown | Reference | Reference | ||||
Yes | 0.514 (0.467, 0,565) | 0.513 (0.467, 0.563) | ||||
Radiotherapy | 0.552 | NI | 0.096 | 0.132 | ||
No/unknown | Reference | |||||
Yes | 1.125 (0.965, 1.312) | |||||
Marital status | 0.001 | 0.016 | < 0.001 | 0.011 | ||
Unmarried | Reference | Reference | ||||
Married | 0.898 (0.822, 0.980) | 0.898 (0.827, 0.975) | ||||
