Table 1 U2AF1 mutation: protein sequence and clinical characteristics.
Total | U2AF1mutation protein sequence [case (%)] | Total X2/Z | Total p value | ||
|---|---|---|---|---|---|
S24F | S34Y | Q157P | |||
32 | 9 | 6 | |||
Median VAF | 0.4127(0.0613~0.4902) | 0.397(0.0138~0.4808) | 0.37215(0.0401~0.4196) | 0.535 | |
Age (year) | 55(21~77) | 53(33~69) | 67.5(43~83) | 0.088 | |
Gender (male) | 23(71.9) | 8(88.9) | 2(33.3) | 4.854 | 0.091 |
MDS subtype 1 | 1.154 | 0.655 | |||
MDS-SLD and -MLD | 12(37.5) | 5(55.6) | 2(33.3) | ||
MDS-EB1 + EB2 | 20(62.5) | 4(44.4) | 4(66.7) | ||
MDS subtype 2 | 9.350 | 0.097 | |||
MDS-SLD | 3(9.4) | 1(11.1) | 2(33.3) | ||
MDS-MLD | 9(28.1) | 4(44.4) | 0(0) | ||
MDS-EB1 | 7(21.9) | 0(0) | 3(50) | ||
MDS-EB2 | 13(40.6) | 4(44.4) | 1(16.7) | ||
IPSS-R group | 1.291 | 0.633 | |||
Relatively low risk group | 7(21.9) | 2(22.2) | 0(0) | ||
Relatively high risk group | 25(78.1) | 7(77.8) | 6(100) | ||
Laboratory Results | |||||
BM blast at diagnosis (%) | 6.2(0.4~18.4) | 4.8(0.4~14) | 1.25(1~2.5) | 0.752 | |
N (109/L) | 0.77(0.06~8.63) | 0.6(0.03~8.1) | 1.16(0.32~6.5) | 0.603 | |
PLT (109/L) | 52(7~459) | 38(29~394) | 50(14~118) | 0.86 | |
HGB (g/L) | 73.5(28~131) | 102(45~145) | 61.5(49~87) | 0.245 | |
Chromosomal abnormality | 13(40.6) | 6(66.7) | 4(66.7) | 2.706 | 0.323 |
Chromosome 7 abnormality | 2(6.3) | 0(0) | 4(66.7) | 11.659 | 0.002 |
Chromosome 8 abnormality | 6(18.8) | 4(44.4) | 0(0) | 3.922 | 0.102 |
Chromosome 20 abnormality | 5(15.6) | 2(22.2) | 0(0) | 1.172 | 0.574 |
Complex karyotype (≥ 3) | 1(3.1) | 0(0) | 1(16.7) | 2.577 | 0.275 |
DEC treatment response | 0.913 | 0.738 | |||
Non-ORR | 13(65) | 3(60) | 5(83.3) | ||
ORR | 7(35) | 2(40) | 1(16.7) | ||
Total | |||||
Relapse | 4(12.5) | 0(0) | 0(0) | 1.028 | 0.750 |
Transformed to AL | 4(12.5) | 1(11.1) | 0(0) | 0.538 | 1.000 |
Median OS (day) | |||||
Co-mutation gene | |||||
TET2 mutation | 8(25) | 3(33.3) | 4(66.7) | 3.849 | 0.134 |
ASXL1 mutation | 13(40.6) | 3(33.3) | 1(16.7) | 1.153 | 0.660 |
RUNX1 mutation | 8(25) | 1(11.1) | 1(16.7) | 0.713 | 0.860 |
TP53 mutation | 1(3.1) | 0(0) | 1(16.7) | 2.577 | 0.275 |
Epigenetic gene (+) | 18(56.3) | 4(44.4) | 4(66.7) | 0.806 | 0.744 |
Signal pathway gene (+) | 6(18.8) | 1(11.1) | 4(66.7) | 6.074 | 0.040 |
Other pathway gene (+) | 10(31.3) | 2(22.2) | 3(50) | 1.34 | 0.450 |
Number of co-mutation genes | 8.396 | 0.160 | |||
0 | 9(28.1) | 3(33.3) | 0(0) | ||
1 | 11(34.4) | 2(22.2) | 1(16.7) | ||
2 | 2(6.3) | 2(22.2) | 3(50) | ||
≧ 3 | 10(31.3) | 2(22.2) | 2(33.3) | ||
