Figure 4
DE-71 exposure produces greater glucose intolerance after perinatal exposure compared to adult exposure. Mice were fasted for 11 h ON and tail blood was sampled for glucose before (t = 0 min) and after (t = 15, 30, 60 and 120 min) i.p. injection of 2.0 g/kg glucose. Absolute blood glucose concentrations taken during IPGTT of F1 (a) and F0 (d). Mean values for the integrated area under the IPGTT glucose curve (AUCIPGTTglucose) show increased glycemia for F1 (b) but not F0 (e). Blood glucose values taken during IPGTT are plotted versus time as a percent of basal glucose for F1 (g) and F0 (i). Mean values for integrated area under the IPGTT glucose percent basal curve (AUCIPGTTglucose) show increased glycemia for both F1 (h) and F0 (j). Latency to maximum glycemia for F1 (c) and F0 (f). *Indicates significantly different from VEH/CON (*P < .05, **P < .01); ^indicates significantly different from 0.1 mg/kg DE-71 (^P < .05, ^^P < .01). Tukey’s or Dunnett’s post hoc tests were used. The symbol “a” indicates the time points at which glycemia is not different from basal in the corresponding treatment group. Glycemia at all other time points differs from basal. Bars and error bars represent mean ± s.e.m. n = 7–12/group. F1 female offspring, F0 dams.
