Figure 7 | Scientific Reports

Figure 7

From: Maternal transfer of environmentally relevant polybrominated diphenyl ethers (PBDEs) produces a diabetic phenotype and disrupts glucoregulatory hormones and hepatic endocannabinoids in adult mouse female offspring

Figure 7

DE-71 exposure increases adrenal epinephrine content in F0 and F1 females and decreases brown adipose tissue (BAT) mass in F1 female mice. (a) Epinephrine content measured in adrenal glands harvested at necropsy was elevated in F0 and F1 females exposed to either dose of DE-71. No change in adrenal weight was measured (data not shown). (b) Interscapular brown adipose tissue (BAT) collected at necropsy was expressed as a percent of body weight. DE-71 exposure produces reduced BAT mass in F1 at 0.1 mg/kg. No effects were seen in F0. *Indicates significantly different from VEH/CON (*P < .05, **P < .01, ***P < .001, ****P < .0001); ^indicates significantly different from 0.1 mg/kg DE-71 (^P < 0.05). Dunnett’s T3 or Tukey’s post-hoc tests were used. Bars and error bars represent mean ± s.e.m. n = 4–8/group for epinephrine and n = 11–32/group for BAT. BAT brown adipose tissue, F1 female offspring, F0 dams.

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