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Figure 1

From: Paradoxical risk of reduced fertility after exposure of prepubertal mice to vincristine or cyclophosphamide at low gonadotoxic doses in humans

Figure 1

Short-term impact of CYP or VCR exposure on prepubertal testes. Box plots representing (a) median body weight, (b) median testis weight and (c) median ratio of testicular weight to body weight of 6-day-old (D6) mice treated with NaCl 0.9%, VCR or CYP at 3 days of age. Morphological alterations of the seminiferous tubules were assessed semi-quantitatively by calculating a global lesional score (d). Representative microscopy images of HES-stained D6 mouse testicular tissues are shown at a × 400 magnification (e). Panels on the lower left corner and lower right corner represent enlarged views of pyknotic nuclei (black arrows) and vacuoles (asterisks). Median is indicated by an horizontal line and points represent individual data with n = 6 mice for NaCl 0.9%, VCR and CYP groups. *P < 0.05 compared to NaCl 0.9% group at the same age.

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