Table 1 Percentage of seminiferous tubules at the most advanced differentiation stage of spermatogenesis in D66 and D140 mice exposed to chemotherapy (VCR or CYP) or unexposed (NaCl 0.9%) during the prepubertal period.
% of seminiferous tubules at the most advanced stage | ||||||
|---|---|---|---|---|---|---|
D66 | D140 | |||||
NaCl 0.9% | VCR | CYP | NaCl 0.9% | VCR | CYP | |
No germ cell (Sertoli cell-only) | 0.0 | 0.3 ± 0.3 | 0.0 | 0.0 | 0.6 ± 0.4 | 0.0 |
Spermatogonia | 0.0 | 0.0 | 0.0 | 0.0 | 0.6 ± 0.4 | 0.0 |
Leptotene/zygotene spermatocytes | 0.0 | 0.0 | 0.0 | 0.0 | 1.4 ± 0.6* | 0.0 |
Pachytene spermatocytes | 0.6 ± 0.4 | 3.3 ± 1.0* | 0.3 ± 0.3 | 0.3 ± 0.3 | 2.8 ± 0.7* | 0.6 ± 0.4 |
Round spermatids | 3.6 ± 1.0 | 7.5 ± 2.5 | 3.9 ± 1.1 | 3.3 ± 0.8 | 15.0 ± 2.0*a | 4.7 ± 0.8 |
Elongating spermatids | 3.9 ± 1.0 | 3.6 ± 0.5 | 4.7 ± 1.2 | 5.3 ± 0.8 | 7.5 ± 1.4 a | 7.2 ± 1.1 |
Elongated spermatids | 92.2 ± 1.1 | 85.8 ± 3.1 | 91.1 ± 1.5 | 91.1 ± 1.1 | 72.2 ± 2.1*a | 87.8 ± 1.5 |
