Figure 4 | Scientific Reports

Figure 4

From: Pharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer

Figure 4

Targeting the mitotic spindle. (A) Heatmap showing the Z-normalized hallmark pathways across PDX models. Row side bar reflects the standard deviation of raw scores. (B) Bi-directional hierarchical clustering of AUC values for drugs that target the mitotic spindle through multiple mechanisms. Color scale = 0 (Inactive) to 1 (Strong active), VB subtype, Vanderbilt molecular classification purposed by Lehmann et al. (2011). BL1, basal-like 1; BL2, basal-like 2; IM, immunomodulatory; LAR, luminal androgen receptor; M, mesenchymal; UNS, unstable. (C–E) Dose–response curves of a prototypic taxane (docetaxel), vinca alkaloid (vincristine sulfate), and KSP inhibitor (SB-743921), respectively.

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