Figure 2 | Scientific Reports

Figure 2

From: Spatial cell type composition in normal and Alzheimers human brains is revealed using integrated mouse and human single cell RNA sequencing

Figure 2

A comparison of cell-type estimate PCC using the data from each of the three scRNA-Seq datasets. (A) Representative examples of the cell-type proportions for each scRNA-Seq input on Donor 10021. MusNG A MusNG simulated sample deconvoluted using the cell types from MusNG, HumN + MusNG A HumN + MusNG simulated sample deconvoluted using the cell types from HumN + MusNG, HumNG + MusNG A HumNG + MusNG simulated sample deconvoluted using the cell types from HumNG + MusNG. (B) Pearson’s correlation coefficients (PCC) distribution between the true proportions of cell types from simulated tissue samples and predicted proportions across nine cell types among repeats for the OLS and NMFR comparison. (C) PCC distribution between true proportions of cell types from simulated tissue samples and predicted proportion baseline comparison between DWLS and OLS using the same gene set. For (B) and (C) the experiments were repeated 100 times for each scRNA-Seq dataset, regression method, and Allen Human Brain Atlas (AHBA) donor. ***Indicates p-value < 0.001.

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