Figure 1
Aromatase inhibitor treatment normalizes the sex steroid levels and consequently IgE and IgG1 levels in AROM+ males. (A) Estradiol and testosterone concentrations at the age of 10 weeks (p70) in WT and AROM+ male mice with and without aromatase inhibitor treatment (n = 10 per group). (B) Total plasma IgE concentration in 7-week old (p48) AROM+ and WT males and females. There was a clear sex difference in WT animals, and the AROM+ males differed significantly from the WT male but not from the WT females (n = 13–16 per group). (C) Plasma IgE levels at the age of 10 weeks (p70) in WT and AROM+ male mice with and without aromatase inhibitor treatment: Inhibitor treatment rescued the increased IgE levels in AROM+ males (n = 10 per group). (D) Plasma IgE levels in the WT and ArKO male and female mice (n = 5–10 per group). The lack of functional aromatase enzyme significantly decreased the IgE levels in female mice. Data presented as median and interquartile range, Mann–Whitney test P: ≤ 0.05 (*), ≤ 0.01 (**), and ≤ 0.0001 (****).
