Table 2 Univariable regression analysis for a poor mRS outcome at 2 weeks.

From: Disentangling etiologies of CNS infections in Singapore using multiple correspondence analysis and random forest

Variable

OR (95% CI)

p-value

Age > 65

6.8 (2.8–18.0)

 < 0.001

Female

1.5 (0.8–3.0)

0.232

Immunocompromised(a)

2.6 (1.2–5.5)

0.015

HIV positive

1.2 (0.2–4.6)

0.842

Altered mental status

34.4 (12.0–125.2)

 < 0.001

Facial focal neurological signs

9.0 (4.2–19.9)

 < 0.001

Muscle weakness

28.5 (11.0–85.5)

 < 0.001

CSF protein abnormal(b)

1.5 (0.7–3.4)

0.344

CSF to blood glucose ratio low(c)

1.8 (0.8–4.8)

0.186

Neck stiffness

2.3 (1.1–5.1)

0.035

Poor mRS score at enrolment

128.0 (40.1–582.3)

 < 0.001

Low sodium(d)

1.2 (0.6–2.4)

0.619

Abnormal movement

9.3 (2.1–63.9)

0.007

High CSF pressure

0.5 (0.2–1.2)

0.148

High WBC count(e)

1.5 (0.8–3.0)

0.237

Low WBC count(e)

0.5 (0.03–3.4)

0.560

% neutrophils in CSF > 80%

1.1(0.23–4.2)

0.886

CSF white blood cells count 5–200(f)

0.73 (0.24–2.34)

0.576

CSF white blood cells count > 200(f)

0.46 (0.14–1.6)

0.212

  1. (a)Defined as history of diabetes, history of liver disease, history of renal disease, history of bone marrow transplant, history of solid organ transplant, or history of steroid use.
  2. (b)Compared to normal protein level of 10–40 mg/dl.
  3. (c)Defined as < 0.6.
  4. (d)Defined as < 135 mEq/L.
  5. (e)Compared to reference normal range of 3.5–11 × 106/mL.
  6. (f)Compared to reference of CSF white cells count ≤ 4/ul.
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