Table 2 COS, IVF outcomes and OS markers in FF.

From: Growth hormone alleviates oxidative stress and improves oocyte quality in Chinese women with polycystic ovary syndrome: a randomized controlled trial

 

PCOS-T (n = 50)

PCOS-C (n = 50)

Non-PCOS (n = 50)

Clinical outcomes

Total dose of rFSH (IU)a,b

1791.74 ± 400.29

1821.02 ± 476.91

2119.75 ± 648.21

Duration of COS (d)

10.48 ± 1.87

10.56 ± 1.79

10.26 ± 1.69

E2 on trigger day (pg/mL)a,b

3903.74 ± 2532.36

4011.30 ± 2887.39

2632.99 ± 1217.87

E2/No. follicles ≥ 14 mm on trigger day (pg/mL)

268.27 ± 46.57

279.65 ± 52.33

259.87 ± 45.38

E2/No. MII (pg/mL)

321.56 ± 51.18

335.47 ± 61.62

317.69 ± 59.36

No. severe OHSS

0

0

0

Embryological and pregnancy outcomes

No. oocytes retrieveda,b

15.52 ± 7.96

14.64 ± 6.49

11.72 ± 4.99

No. MII

12.30 ± 6.80

10.02 ± 6.48

9.94 ± 5.30

No. fertilized oocytes (2PN)c

8.80 ± 4.84

6.46 ± 4.61

7.34 ± 3.91

No. cleaved embryosc

6.30 ± 4.51

4.32 ± 3.08

5.02 ± 3.62

No. higher-quality embryos

3.32 ± 3.05

2.46 ± 2.25

3.00 ± 2.96

No. embryos transferred

1.74 ± 0.44

1.78 ± 0.42

1.78 ± 0.42

Implantation rate (%)

36.78% (32/87)

29.21% (26/89)

33.71% (30/89)

Clinical pregnancy rate/ET (%)

54.00% (27/50)

42.00% (21/50)

50.00% (25/50)

Early miscarriage rate (%)

7.41% (2/27)

9.52% (2/21)

4.00% (1/25)

Multiple pregnancy rate (%)

18.50% (5/27)

23.80% (5/21)

20.00% (5/25)

FF oxidative status

FF MDA (µmol/L)

2.50 ± 1.25

2.51 ± 0.82

2.19 ± 0.70

FF SOD (U/mg prot)

13.81 ± 1.50

13.81 ± 1.53

13.90 ± 2.11

FF TAC (mmol Trolox Eq/L)

0.68 ± 0.09

0.68 ± 0.08

0.64 ± 0.10

FF TOS (µmol H2O2 Eq/L)b,c

8.16 ± 1.88

10.48 ± 2.68

8.38 ± 2.35

FF OSIb,c

12.34 ± 3.90

15.59 ± 5.32

13.10 ± 4.78

  1. Data are presented as mean ± SD or number (percentage).
  2. 2PN number of two pronuclear zygotes, OHSS ovarian hyperstimulation syndrome, MDA malondialdehyde, SOD superoxide dismutase, TAC total antioxidant capacity, TOS total oxidant status, OSI oxidative stress index.
  3. aP < 0.05 PCOS-T versus non-PCOS.
  4. bP < 0.05 PCOS-C versus non-PCOS.
  5. cP < 0.05 PCOS-T versus PCOS-C.