Figure 8
From: Anti-cancer potential of persimmon (Diospyros kaki) leaves via the PDGFR-Rac-JNK pathway
A proposed model of the EEDK-induced cell death pathway. EEDK could activate the PDGFR-Rac-JNK signaling axis. In cancerous cells, which have high basal JNK activity, enhanced JNK activity exceeds a normal range of JNK activation, leading to JNK-AP-1/p53 mediated cell death. However, the same amount of EEDK is not sufficient to exceed the normal range of JNK activity in normal cells, which has low basal JNK activation, resulting in cell proliferation. Besides, EEDK could suppress Wnt/β-catenin pathway by promoting βTrCP expression and intracellular Ca2+ concentration. This figure was created using BioRender (https://biorender.com/).
