Table 2 Effect of UEDR on relative organ weight (ROW) in the subchronic oral toxicity study (× 10−3).
From: Toxicological evaluation of the ultrasonic extract from Dichroae radix in mice and wistar rats
Index | 28 days treatment (g/kg BW/day) | 14 days withdrawal | ||||||
|---|---|---|---|---|---|---|---|---|
Control | 0.15 | 0.30 | 0.60 | Control | 0.15 | 0.30 | 0.60 | |
Female ♀ | ||||||||
Heart | 3.94 ± 0.12 | 4.06 ± 0.07 | 4.24 ± 0.38 | 4.92 ± 0.08* | 3.80 ± 0.11 | 3.42 ± 0.16 | 3.58 ± 0.19 | 3.90 ± 0.15 |
Liver | 39.56 ± 0.26 | 38.36 ± 0.44 | 38.04 ± 0.51 | 36.98 ± 0.69** | 37.00 ± 0.66 | 36.22 ± 0.54 | 37.48 ± 0.51 | 36.50 ± 0.62 |
Spleen | 2.08 ± 0.12 | 2.16 ± 0.09 | 2.16 ± 0.10 | 2.04 ± 0.13 | 2.06 ± 0.68 | 1.96 ± 0.24 | 2.00 ± 0.04 | 2.00 ± 0.00 |
Lung | 5.92 ± 0.19 | 6.22 ± 0.20 | 6.40 ± 0.14 | 6.68 ± 0.15* | 6.34 ± 0.14 | 5.96 ± 0.21 | 6.40 ± 0.11 | 6.10 ± 0.00 |
Kidney | 6.86 ± 0.17 | 7.24 ± 0.12 | 7.56 ± 0.13* | 7.64 ± 0.21** | 6.82 ± 0.14 | 6.66 ± 0.23 | 6.90 ± 0.21 | 6.43 ± 0.17 |
Stomach | 98.38 ± 0.68 | 99.12 ± 0.82 | 100.16 ± 0.44 | 99.72 ± 0.48 | 99.34 ± 0.55 | 99.18 ± 0.53 | 99.68 ± 0.71 | 100.03 ± 0.33 |
Thymus | 1.33 ± 0.04 | 1.39 ± 0.02 | 1.40 ± 0.02 | 1.43 ± 0.02 | 0.97 ± 0.01 | 0.98 ± 0.01 | 0.99 ± 0.01 | 0.98 ± 0.01 |
Ovary | 0.59 ± 0.01 | 0.60 ± 0.01 | 0.58 ± 0.02 | 0.59 ± 0.01 | 0.54 ± 0.01 | 0.56 ± 0.01 | 0.54 ± 0.01 | 0.53 ± 0.02 |
Uterus | 1.58 ± 0.04 | 1.58 ± 0.02 | 1.60 ± 0.02 | 1.61 ± 0.01 | 1.42 ± 0.02 | 1.48 ± 0.01 | 1.42 ± 0.02 | 1.44 ± 0.04 |
Male ♂ | ||||||||
Heart | 3.46 ± 0.13 | 3.48 ± 0.13 | 3.32 ± 0.19 | 3.38 ± 0.10 | 3.42 ± 0.08 | 3.46 ± 0.05 | 3.28 ± 0.92 | 3.25 ± 0.06 |
Liver | 38.08 ± 0.31 | 37.54 ± 0.20 | 37.40 ± 0.17 | 37.04 ± 0.26* | 35.18 ± 0.97 | 35.36 ± 1.05 | 35.98 ± 0.79 | 37.40 ± 0.15 |
Spleen | 2.28 ± 0.08 | 2.20 ± 0.22 | 2.08 ± 0.12 | 2.10 ± 0.10 | 1.76 ± 0.07 | 2.02 ± 0.18 | 1.96 ± 0.10 | 2.05 ± 0.13 |
Lung | 4.92 ± 0.24 | 6.16 ± 0.52 | 5.76 ± 0.25 | 6.42 ± 0.58* | 5.48 ± 0.14 | 5.18 ± 0.10 | 5.32 ± 0.19 | 5.82 ± 0.48 |
Kidney | 6.16 ± 0.24 | 6.92 ± 0.24 | 6.56 ± 0.33 | 7.18 ± 0.26* | 5.90 ± 0.11 | 5.92 ± 0.08 | 5.88 ± 0.11 | 5.92 ± 0.48 |
Stomach | 94.40 ± 2.06 | 92.54 ± 0.68 | 91.46 ± 0.79 | 88.90 ± 1.22 | 98.06 ± 0.43 | 96.74 ± 0.70 | 96.70 ± 0.25 | 98.15 ± 0.72 |
Thymus | 1.34 ± 0.04 | 1.40 ± 0.01 | 1.39 ± 0.01 | 1.38 ± 0.02 | 1.01 ± 0.02 | 1.01 ± 0.01 | 1.00 ± 0.01 | 1.00 ± 0.02 |
Testicle | 9.24 ± 0.22 | 9.34 ± 0.12 | 9.48 ± 0.07 | 9.40 ± 0.19 | 8.70 ± 0.07 | 8.51 ± 0.07 | 8.52 ± 0.12 | 8.62 ± 0.06 |
