Figure 3

Rapid, centimeter-scale MPM ex vivo imaging of freshly excised facial skin at sub-micron resolution. MPM overview map (80 MPx, 1.2 × 1.0 cm2) of a centimeter-scale skin tissue (a) prior and (b) post CARE processing, acquired as a single frame by strip mosaic scanning at 30 μm depth in the epidermis. The insets represent digital zoom-in of the 200 × 200 μm2 outlined areas in (a) and (b). The intensity profiles (red) through adjacent keratinocytes show that image restoration enhances contrast to allow visualization of keratinocyte nuclei.