Table 2 Loci significantly associated with both excessive alcohol consumption and γ-GT.

From: CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption

Gene

Start

End

Minimum p value of drinking

Number of overlapping SNPs

ALDH2

112204691

112247782

1.73E−96

20

ACAD10

112123857

112194903

3.78E−96

31

BRAP

112079950

112123790

7.68E−96

24

HECTD4

112597992

112819896

1.19E−94

185

PTPN11

112856155

112947717

8.45E−94

11

NAA25

112464500

112546826

2.27E−91

71

TRAFD1

112563305

112591407

8.44E−90

16

RPH3A

113008184

113336686

6.35E−80

188

RPL6

112842994

112856642

5.46E−76

2

CUX2

111471828

111788358

2.76E−66

39

MYL2

111348623

111358526

1.05E−43

30

CCDC63

111284573

111345339

7.33E−43

65

ATXN2

111890018

112037480

2.60E−39

86

TMEM116

112369086

112450970

1.35E−29

117

MAPKAPK5

112279782

112334343

1.36E−25

100

SH2B3

111843752

111889427

9.87E−25

18

ERP29

112451120

112461255

3.54E−20

9

IFT81

110562140

110656602

2.47E−19

3

  1. Adjusted for age, sex, and 10 principal components. ALDH2: aldehyde dehydrogenase 2, ACAD10: acyl-coenzyme A dehydrogenase family, member 10, BRAP: breast cancer 1-associated protein, HECTD4: HECT domain E3 ubiquitin protein ligase 4, PTPN11: protein tyrosine phosphatase non-receptor type 11, NAA25: N(alpha)-acetyltransferase 25, TRAFD1: TRAF-type zinc finger domain containing 1, RPH3A: rabphilin 3A, RPL6: ribosomal protein L6, CUX2: cut-like homeobox 2, MYL2: myosin, light polypeptide 2, ATXN2: ataxin 2, CCDC63: coiled-coil domain containing 63, TMEM116: transmembrane protein 116, MAPKAPK5: MAP kinase activated protein kinase 5, SH2B3: SH2B adaptor protein 3, ERP29: endoplasmic reticulum protein 29, IFT81: intraflagellar transport 81.
Back to article page