Figure 3
From: Increased intestinal permeability and gut dysbiosis in the R6/2 mouse model of Huntington’s disease
R6/2 and WT mice gut microbiota analysis. Gut microbiota composition at phylum and genus level using16S rRNA analysis of faecal samples from 16 weeks of age mice (n = 9–10/genotype) (A). Partial least squares (PLS-X) loading and score scatter plots of different gut microbial taxa and biomarkers (blue) from R6/2 and WT mice (n = 4–6/genotype). Firmicutes taxa (purple) are associated with WT, while Bacteroidetes taxa (brown), FD4 permeability (Perm) and glucose levels (Gluc) are strongly associated with R6/2. R6/2 mice show an increased relative abundance of Bacteroidetes and a decreased relative abundance of Firmicutes (B).
