Table 1 Body weight, body length, intestinal length and serum glucose levels in R6/2 and wild type littermates at 12 and 16 weeks of age.

From: Increased intestinal permeability and gut dysbiosis in the R6/2 mouse model of Huntington’s disease

 

WT

R6/2

P-value

Age (weeks)

12

16

12

16

12

16

Body weight (g)

27.9 ± 0.9

30.0 ± 1.1

24.7 ± 0.6

19.5 ± 0.8

0.04

0.0012

Body length (cm)

8.9 ± 0.1

9.3 ± 0.01

9.0 ± 0.1

8.3 ± 0.0

0.5

0.002

Glucose levels (mM/L)

13.7 ± 1.0

15.02 ± 2.0

15.93 ± 1.7

26.6 ± 2.9

0.26

0.0013

Small intestine length (cm)

37.6 ± 1.0

35.1 ± 0.7

38.1 ± 1.0

36.8 ± 0.9

0.7

0.10

Colon length (cm)

8.7 ± 0.2

9 ± 0.2

7.6 ± 0.4

8 ± 0.2

0.06

0.01

  1. R6/2 mice exhibit significantly reduced body weight and body length at 16 weeks of age. R6/2 mice have high blood glucose levels at 16 weeks of age. Colon length is significantly decreased at 16 weeks of age. N = 6–10 for WT; N = 6 for R6 /2; Mann–Whitney test; WT-wild type.
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