Table 2 Brain MRI variables according to the risk of CHA₂DS₂-VASc score.

Brain structure	Intermediate risk of CHA₂DS₂-VASc (n = 9)		High risk of CHA₂DS₂-VASc (n = 40)		p value
Brain structure	Volume (cm³)	% ICV (%)	Volume (cm³)	% ICV (%)	Volume	%ICV
Whole brain	1043.6 (980.8–1154.2)	69.7 (68.4–72.7)	986.0 (918.2–1052.3)	68.9 (67.2–71.5)	0.064	0.408
Superior lateral ventricles	46.9 (28.0–74.8)	3.19 (2.11–4.27)	45.5 (31.3–60.1)	3.03 (2.24–4.19)	0.949	0.970
Thalamus	13.3 (12.3–15.6)	0.89 (0.88–0.95)	12.9 (12.2–13.7)	0.91 (0.85–0.97)	0.313	0.889
Cortical gray matter	458.1 (436.0–499.0)	30.8 (29.5–31.4)	433.1 (404.0–452.8)	30.2 (28.7–31.6)	0.053	0.770
Cerebral white matter	412.8 (358.8–455.1)	27.1 (26.3–28.2)	380.1 (338.2–404.1)	26.0 (25.1–27.7)	0.053	0.107
3rd ventricle	2.71 (1.95–3.60)	0.18 (0.14–0.21)	2.41 (2.12–2.84)	0.17 (0.15–0.20)	0.694	0.751
Hippocampi	6.69 (6.15–6.88)	0.44 (0.42–0.48)	5.93 (5.63–6.44)	0.43 (0.38–0.45)	*0.002*	0.140
Inferior lateral ventricles	3.09 (2.72–3.87)	0.22 (0.19–0.25)	3.79 (2.77–5.00)	0.26 (0.21–0.33)	0.408	0.091
WMH lesion burden
Lesion count (n)	23.0 (6.5–32.5)		25.5 (15.0–50.75)		0.170
Lesion volume (cm³)	3.26 (0.80–5.32)		6.04 (2.78–13.94)		*0.050 (0.0497)*
% ICV (%)	0.17 (0.06–0.36)		0.44 (0.19–0.90)		*0.027*
Lesion Burden	0.64 (0.19–1.44)		1.67 (0.70–3.45)		*0.036*
WMH lesion anatomical distribution (cm³)
Leukocortical	0.09 (0.01–0.27)		0.07 (0.01–0.39)		0.829
Periventricular	2.87 (0.62–4.66)		4.13 (2.32–10.85)		0.077
Deep white matter	0.12 (0.01–0.42)		0.48 (0.19–1.34)		*0.027*

Data are presented as median (25–75th percentiles). High risk of CHA2DS2-VASc score refers to score ≥ 2 in men or ≥ 3 in women and intermediate risk of CHA2DS2-VASc score refers to score 1 in men or score 2 in women.
CHA₂DS₂-VASc: congestive heart failure, hypertension, age ≥ 75 (doubled), diabetes mellitus, prior stroke or transient ischemic attack (doubled), vascular disease, age 65–74, female; ICV, intracranial volume; MRI, magnetic resonance imaging; WMH, white matter hyperintensity.

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