Figure 1

(A,B) Flow cytometry of cixutumumab conjugates in IGF-1R positive MCF-7/Her18 breast cancer. Percentage of bound was estimated from the relative fluorescence intensity and plotted against concentration. (C) Internalization of cixutumumab antibody conjugates in MCF-7/Her18 cells. All data shown as a mean of 6 wells ± SEM.