Figure 3 | Scientific Reports

Figure 3

From: Identification of a juvenile-hormone signaling inhibitor via high-throughput screening of a chemical library

Figure 3

Hit compounds from HTS using BmN_JF&AR cells. (A) The heat map represents the results of the fourth screening. Compounds in the fourth screening were assigned numbers (analog and dose–response test [ADT] no., ADTX-Y). X numbers (left) showed the compound groups, and Y numbers show each analog in the compound group; the top line for each group (ADTX-1) show compound hits identified during the third screening, and the subsequent lines (ADTX-2, -3, -4…) show analogs of ADTX-1. Plus (red) and minus (green) values of InH (%) indicate JHSI and JHSA activities, respectively. (B) Differences in the functional groups converted JHSIs into JHSAs. Pink shading show differences in the functional groups. (C) 4-phenoxyphenoxymethyl-like compounds possessed JHSI activity. 4-phenoxyphenoxymethyl (light blue shading) was the basic structure of pyriproxyfen and fenoxycarb, two known JH agonists.

Back to article page