Table 3 Gene Ontology (GO) analysis on selected HSCs genes
From: Silencing of sinusoidal DDR1 reduces murine liver metastasis by colon carcinoma
Downregulated | P value | |
|---|---|---|
Collagen fibril organization | Col2α1, Col3α1,Col14α1, Loxl3 | 1.23E−06 |
Collagen catabolic process | Mmp3, Mmp9, Mmp12, Mmp13 | 4.96E−08 |
Inflammatory response | Il1a, Il1b, Il6, Il13, Il18, Il1rn, Il1rl2 | 3.02E−05 |
Inflammatory response | Cxcl1, Cxcl2, Cxcl5, Cxcl9, Cxcl10, Cxcl11, Cxcl12, Cxcl13 | 7.81E−08 |
Regulation of inflammatory response | Tnf , Tnfrsf11a, Tnfsf4, Tnfaip3, Tnfaip6 | 3.22E−04 |
Chemokine-mediated signaling pathway | Cxcl1, Cxcl2, Cxcl5, Cxcl9, Cxcl10, Cxcl11, Cxcl12, Cxcl13 | 2.53E−17 |
Regulation of cell proliferation | Pdgfra, Pdgfrb, Pdgfc, Fap, Csf1, Csf2, Stat1, Fgfr1op | 7.67E−04 |
Cell adhesion | Tnc, Lamb1-1, Vcan, Lama4, Dag1, Hpse | 5.54E−03 |
Protein autoprocessing | Casp1, Casp 12 | 4.74E−03 |
Upregulated | P value | |
|---|---|---|
Mitotic cell cycle | Cdkn1a, Ccno, Ccng1, Hus1, Gtse1, Cep55, Ckap2 | 3.14E−02 |
Regulation of cyclin-dependent protein serine/threonine kinase activity | Cdkn1a, Akt1, Ccno, Ccng1 | 2.84E−02 |
Regulation of protein phosphorylation | Cdkn1a, Akt1, Ccno, Ccng1, Hus1, Cblb, Gdf15, Ccl19, Ifna2 | 4.42E−02 |
